Ganglioside galactosyltransferase
| ganglioside galactosyltransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 2.4.1.62 | ||||||
| CAS number | 37217-28-0 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a ganglioside galactosyltransferase (EC 2.4.1.62) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
The 2 substrates of this enzyme are UDP-galactose and N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine, whereas its 2 products are UDP and D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase. Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl), galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.
References
- Basu S, Kaufman B, Roseman S (1965). "Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase". J. Biol. Chem. 240 (10): 4115–7. PMID 5842076.
- Yip GB, Dain JA (1970). "The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram ide galactosyltransferase in rat brain". Biochim. Biophys. Acta. 206 (2): 252–60. PMID 4987145.
- Yip MC, Dain JA (1970). "Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosy lceram ide galactosyltransferase". Biochem. J. 118 (2): 247–52. PMC 1179110. PMID 5484669. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1179110.